Abstract:Nanjing Kexiang Area was once a reasonable and livable urban public space form. However, with the changes of external social environment, especially the impact of the 2020 Covid-19 epidemic, many problems and contradictions were created in alleys, and the risk of health management was generated in special times. This paper selects six streets and alleys in Kexiang District of Nanjing as the research object, conducts research and analysis from three perspectives of street space system, cultural system and users. By combing the existing problems, the paper puts forward the design strategies of urban smallscale regeneration from the perspective of healthy life: the intensive utilization of street space, the continuation of street furniture to street culture, and the construction of a intelligent and ecological healthy life system.